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mavorixafor will raise the amount or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a strong CYP2D6 inhibitor) is contraindicated with prescription drugs that happen to be hugely dependent on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine each increase sedation. Steer clear of or Use A